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HIV p24-env Type 1
Protein |
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This protein is a 256 amino
acid fusion protein consisting of the type 1 HIV
p24 core polypeptide with a conserved, highly
immunoreactive envelope polypeptide sequence
derived from HIV-1 envelope inserted at the gene
level. The protein which has been subjected to
extensive purification produces a single band on
SDS and is soluble in physiological buffer. The
p24-env type 1 protein does not contain any
non-HIV related sequences and it has proven to
be a highly effective antigen to detect anti-HIV
antibodies in infected individuals. For an SDS
gel analysis image of the purified protein,
see Lane 3 on the gel image (left). |
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HIV p24-env Type 2
Protein |
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This protein is a 258 amino
acid fusion protein consisting the type 1 HIV
p24 core polypeptide with a conserved, highly
immunoreactive envelope polypeptide sequence
derived from HIV-2 envelope inserted at the gene
level. The protein which has been subjected to
extensive purification produces a single band on
SDS and is soluble in physiological buffer. The
HIV type 2 p24 env recombinant polypeptide
contains no non-HIV related sequences. It has
proven highly effective in detecting HIV type 2
antibodies in sera from individuals infected
with this virus. For an SDS gel analysis image of
the purified protein, see lane 4 on the gel
image (left). |
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HIV p24-env Type O
Protein |
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This protein is a 258 amino
acid fusion protein consisting the type 1 HIV
p24 core polypeptide with a conserved, highly
immunoreactive envelope polypeptide sequence
designed using a consensus sequence of various
HIV type O envelope species which were
synthetically prepared and inserted into the p24
gene prior to expression. The protein which has
been subjected to extensive purification,
produces a single band on SDS and is soluble in
physiological buffer. The HIV Type O p24 env
recombinant polypeptide contains no non-HIV
related sequences. Due to the scarcity of type O
antisera from individuals infected with this
viral variant, no extensive documentation has
been possible, however, reports from clients
having gained experience with the protein
indicate strong reactivity with such sera. For
an SDS gel analysis image of the purified
protein, see lane 5 on te gel image (left).
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